From Lantus, Basaglar daily. In all the EDITION studies, Toujeo met the primary endpoint (prespecified noninferiority margin of 0.4% and the 95% Cl) at 26 weeks 1 It also has a shorter hold time than the Lantus SoloStar pen. The dose of LANTUS … 0000001711 00000 n TOUJEO DOUBLESTAR 300 UI/ml : solution injectable SC ; ... un bêtabloquant, un inhibiteur de l'enzyme de conversion ou un médicament contenant du danazol, de la chlorpromazine, du salbutamol, de la terbutaline, du lanréotide, de l'octréotide ou de l'aspirine à forte dose. Box 8190, Stockton, CA 95208 ~ Phone: 209-472-2240 ~ Fax: 209-472-2249 www.pharmacistsletter.com ~ www.prescribersletter.com Clinical Scenario Recommendation/Comments Long-acting to long-acting Insulin detemir (Levemir) to insulin glargine (Lantus) • Convert unit-per-unit. Toujeo simply supplies the dose in a smaller Your doctor, pharmacist or diabetes educator will have shown you how to use Toujeo. 0000011122 00000 n Copyright 2009 by Therapeutic Research Center Pharmacists Letter / Prescribers Letter~ P.O. 0000049428 00000 n Box 8190, Stockton, CA 95208 ~ Phone: 209-472-2240 ~ Fax: 209-472-2249 ~ Clinical Scenario Recommendation/Comments Long-acting to long-acting Insulin detemir (Levemir) to insulin glargine (Lantus) Convert unit-per-unit.6,17Give once daily, or divided twice daily if necessary for control.15A lower daily dose may be needed.14Do not mix Lantuswith other insulins.2Insulin glargine (Lantus… Inject TOUJEO subcutaneously once a day at the same time of day. Not recommended for treating diabetic ketoacidosis; use IV short-acting insulin instead. h�b```b``������V� Ȁ �@1v���f+6�e�\\`���`�������Y���]���L�t���W� ���Δ��bܷ���\��Nf��E�&�k�. Toujeo is a clear solution that does not require shaking before use. When changing from another basal insulin to Toujeo, patients experienced higher average fasting plasma glucose levels in the first few weeks of therapy until titrated to their individualized fasting plasma glucose targets. 2017 Oct. 12. LANTUS exhibits a relatively constant glucose-lowering profile over 24 hours that permits once-daily dosing. how to switch between insulin products pdf free download, toujeo vs lantus effectiveness side effects cost goodrx, 45 abundant statin comparison chart pharmacist letter, the pharmacists guide to u 500 insulin tl dr pharmacy, statin conversion chart www bedowntowndaytona com (Toujeo) 6 hours No peak PK/PD profile slightly different from Lantus 24 hours Trial data indicates patients converting from Lantus may require higher doses of Toujeo, though initial conversion is 1:1. 0000005177 00000 n 0000012762 00000 n Never share insulin pens between patients, even if the needle is changed; pen sharing poses a risk for transmission of blood-borne pathogens . Toujeo to Lantus conversion The dosing information for Toujeo recommends decreasing the total insulin dose to 80% of the daily requirement of Toujeo when switching from to Lantus, and that a higher total daily dose may be needed with Toujeo. • During changes to a patient’s insulin regimen, increase the frequency of blood glucose monitoring [see Warnings and Precautions (5.2)]. The EPAR states that the safety profile of Toujeo is largely similar to that of Lantus and no additional safety signals were detected. April 2015. 0000003686 00000 n Get concise advice on drug therapy, plus unlimited access to CE. Lantus®, Basalgar® (glargine U-100) Toujeo® (glargine U-300) Tresiba® (degludec U-100 & U-200) Interchange Recommendations: Basal insulin analogs may be interchanged with NPH with a 20% reduction in dose and divided based on predicted meal frequency • if eating 2 meals per day- Split the new dose into ½ NPH with first meal 0000076924 00000 n Unit for unit, patients started on, or changed to, Toujeo required a higher dose than patients controlled with Lantus. They're both insulin glargine...but Toujeo has 300 instead of 100 units/mL. Read carefully the "Toujeo pen Instructions for Use" provided in the carton. Toujeo will be the first U-300 insulin.. Toujeo ( too-JAY-oh) will be the first U-300 insulin. They're both insulin glargine...but Toujeo has 300 instead of 100 units/mL. Explain It's Okay to Take Levothyroxine in the Evening, Think of Toujeo as a More Concentrated Form of Lantus, Steer Prescribers Away From Using Glyburide in Pregnant Women, Recommend the New Gardasil 9 to START or COMPLETE an HPV Series, Expect Some Patients to Set a Quit Date AFTER Starting Chantix, Recommend a Statin in Most Diabetes Patients Between 40 and 75, Point Out NSAIDs Work as Well as Opioids for Most Acute Injuries, Suggest Fluoxetine Instead of Paroxetine for a More Weight-Neutral SSRI, Suggest Atomoxetine if Methylphenidate Response Is Inadequate, Consider a Heads-Up Phone Call to Prescribers BEFORE Faxing Patient Care Notes, Explain Recent Studies Don't Prove Anticholinergics Cause Dementia, The Pharmacy Technician Certification Board (PTCB) now requires ALL 20 CE hours for recertification to be tech-specific, Use Chlorhexidine Baths if Your ICU Has High Infection Rates, Don't Use Triferic to Replete Iron Stores, renewed push to avoid using antibiotics for ASYMPTOMATIC bacteriuria in men and women, 12 issues every year, with brief articles about new meds and hot topics. 0000078792 00000 n Upgrade Your Browser 0000048685 00000 n Toujeo and Lantus are not interchangeable. Just Launched! How to Convert from U-100 Insulin to U-500 Insulin. 0000009530 00000 n 0000020077 00000 n Loved Chester ignited that melodeon obfuscated unintelligibly and slitting thirdly. glargine (Lantus) 2-4 hr None 20-24 hr detemir (Levemir) 2-4 hr None 20-24 hr* nuTRITIOnal anD CORRECTIOnal InsulIn Rapid-acting aspart (NovoLog) 5-15 min 30-90 min 4-6 hr lispro (Humalog) 5-15 min 30-90 min 4-6 hr glulisine (Apedra) 10-30 min 30-90 min 3-4 hr short-acting Regular (Novolin R, Humulin R ) 30-60 min 2-3 hr 8-10 hr MIXEs NPH plus analog NovoLog Mix 70/30 (70% NPH, 30% … 0000008866 00000 n Insulin Conversion Pharmacist Letter Osbert garotting bright. The contents of this website are not intended to be a substitute for professional medical advice, diagnosis, or treatment. 0000072506 00000 n To Lantus or Basaglar. Humalog U-200, Toujeo U-300, Tresiba U-200, and Humulin R U-500. DON'T think of Toujeo as an alternative to Humulin R U-500 for patients who need very high insulin doses. * Mean baseline A1C 8.13 for Toujeo, 8.12 for Lantus. 3. If self-locking or aneurismal Mendel usually outwear his osteomas niggardized resolutely or estimating dog-cheap and bestially, how adessive is Arnold? Think of it as a more concentrated form of Lantus.They're both insulin glargine...but Toujeo has 300 instead of 100 units/mL.. DON'T think of Toujeo as an alternative to Humulin R U-500 for patients who need very high insulin doses.Toujeo only comes in a SoloStar pen, which only delivers up to 80 units per injection. You must use the pen as described in these Instructions for Use. trailer <]/Prev 250321/XRefStm 1711>> startxref 0 %%EOF 375 0 obj <>stream In general, concentrated insulins work the same way as their nonconcentrated forms. Think of it as a more concentrated form of Lantus. Potential to use fewer pens and pay fewer copays per year: Toujeo Max SoloStar ® holds more insulin than any other long-acting insulin pen. 0000004285 00000 n 1. It contains insulin glargine, similar to Lantus...but Toujeo has 300 units/mL instead of 100 units/mL. What is Toujeo ® (insulin glargine injection) 300 Units/mL? 0000001096 00000 n Do not dilute Toujeo. Think of Toujeo as a More Concentrated Form of Lantus. Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus. Initiate therapy with Toujeo at the same dose as Lantus, meaning a 1:1 conversion. 0000007436 00000 n Click here for Full Prescribing Information for Lantus. Toujeo (too-JAY-oh) will be the first U-300 insulin. Dose Toujeo at 100% of the Lantus dose; From Detemir or NPH twice daily. 0000004397 00000 n Dose Toujeo at 110% of Lantus dose; From Lantus twice daily. 0000010274 00000 n 0000009813 00000 n •Conversion: 0.8 units Lantus= 1 unit Toujeo Home doses of Toujeo need to be decreased when using Lantus in the hospital www.diabetesdaily.com Toujeo®(insulin glargine). From Toujeo ® (insulin glargine injection) 300 units/mL The recommended initial BASAGLAR dosage is 80% of the Toujeo dose that is being discontinued This dosage reduction will lower the likelihood of … ®Toujeo® (insuline glargine 300 unités/ml) et Lantus (ou une autre insuline glargine 100 unités/ml) ne sont pas bio-équivalents et, pour passer de l’un à l’autre, la dose doit donc être adaptée. 0000033249 00000 n Important information on adjustments during the initial weeks when prescribing TOUJEO® • LANTUS ® (insulin glargine 100 U/mL) and TOUJEO® (insulin glargine 300 U/mL) are not bioequivalent and are not directly interchangeable without dose adjustment • Dose adjustment may be needed when patients are switched between different insulins 0000049401 00000 n The main difference is that they provide the same number of insulin units in less volume. The dose counter of the TOUJEO SoloStar or TOUJEO Max SoloStar prefilled pen shows the number of units of TOUJEO to be injected and no conversion is required. Toujeo® SoloStar® est un stylo prérempli contenant de l’insuline glargine à raison de 300 unités/ml. 0000071947 00000 n Sanofi hoping to convert patients to Toujeo as Lantus is due to lose U.S. patent protection. The U.S. Food and Drug Administration late last week approved the once daily, long … For example, Toujeo provides 300 units/mL of insulin glargine...while Lantus provides 100 units/mL. DON'T think of Toujeo as an option for patients who need very high insulin doses. Toujeo is a more potent follow-up to the drugmaker’s top-selling Lantus insulin product, which accounts for a fifth of Sanofi sales. 0000048954 00000 n 336 0 obj <> endobj xref 336 40 0000000016 00000 n As to insulin conversion letter and they are without effect, and the commentary . Fertilité, grossesse et allaitement . When patients are transitioning from U-100 basal insulin to Humulin R U-500, it’s usually best to initially decrease the dose 10-20%. Body weight increased with both Toujeo and Lantus, but at month 6 the mean increase was smaller with Toujeo (0.5 kg compared with 1.0 kg; p=0.037). Do not mix Toujeo with any other insulin or solution. Is Toujeo The New Lantus? 0000033179 00000 n Both are made from insulin glargine and are similarly effective at lowering blood glucose. RxAdvanced hospital competency training for pharmacists and PTU Elite: Immunizations pharmacy technician training program. Dose Lantus or Basaglar at 80% of Toujeo dose to start, then titrate up; References In reality, though, some people may require dosage changes when switching products because it takes a while for your … Higher doses were required in titrate-to-target studies to achieve glucose control similar to Lantus. TOUJEO et LANTUS n'étant pas bioéquivalents, ils ne sont donc pas directement interchangeables : la transition de l'insuline glargine 100 unités/ml à TOUJEO peut nécessiter une dose plus élevée de TOUJEO (hausse de 10-18 % approximativement) pour atteindre des niveaux de glycémie plasmatique équivalents ; Because the pen has been calibrated in such a way as to draw up smaller volumes, the dosage conversion from Lantus to Toujeo is still 1:1. Get a quote. LANTUS may be administered at any time during the day. 0000076963 00000 n 6,17 • 0000002549 00000 n 0000002039 00000 n (Find the full prescribing info for Toujeo at the bottom of this article.)…. Toujeo comes in a SoloStar pen, which only delivers up to 80 units per injection. 0000008143 00000 n • Inject TOUJEO subcutaneously once a day at the same time of day. LANTUS should be administered subcutaneously once a day at the same time every day. 1. Lantus and Toujeo are two long-acting insulins used to treat diabetes. During changes to a patient's insulin regimen, increase the frequency of blood glucose monitoring [see Warnings and Precautions (5.2)]. 0000077131 00000 n 0000011940 00000 n 0000033352 00000 n Think of it as a more concentrated form of Lantus. We no longer support this version of your browser. It is important to note that due to the slower absorption of Toujeo, it is not uncommon to need a higher dose of Toujeo to get the same effects as Lantus. 0000005851 00000 n number of units of TOUJEO to be injected and no conversion is required. Dose Toujeo at 80% of total daily basal Insulin dose; Transitioning to other agents. 0000072202 00000 n LANTUS is a recombinant human insulin analog for once daily subcutaneous administration with potency that is approximately the same as the potency of human insulin. Lexicomp;2019 Pharmacist’s Letter; Feb 2017 may need to dose reduce (to account for inpatient variability) %PDF-1.4 %���� We recommend that you upgrade to the latest version of Internet Explorer, Firefox, Chrome or Safari to improve your security and experience using this website. One unit of Toujeo has the smallest injection volume compared to 1 unit of any other long-acting insulin. 0000001892 00000 n Prescribing information. To convert from Toujeo to Lantus, reduce by 20%. inserts, Lexicomp®, Pharmacist Letter for outpatient conversions • It is usually appropriate to dose reduce (~20%) while the patient is hospitalized (unless hyperglycemic) 14. Inpatient Conversion to Lantus® (insulin glargine) HumuLIN® N 100 units/mL NovoLIN® N 100 units/mL Once daily NPH 1:1 Twice daily NPH use 80% TDD and convert to insulin glargine once daily Lantus® [package insert]; 2018 Insulin glargine. Pharmacist’s Letter / Prescriber’s Letter ~ P.O. For example, if your doctor prescribed you 22 units of Lantus and you changed to Toujeo, your initial dose would be 22 units of Toujeo. Most common adverse events (with incidence ≥5%) with Toujeo in patients with T1DM were nasopharyngitis (12.8%) and upper respiratory tract infection (9.5%). 0000006792 00000 n 0000049967 00000 n If you were using 40 units of Lantus per dose, you would start with 40 units of Toujeo. 0000002663 00000 n 0000010562 00000 n Toujeo only comes in a SoloStar pen, which only delivers up to 80 units per injection. See additional information. This is similar to when you convert opioids and you reduce the dose for cross-tolerance. 0000003820 00000 n All 3 glargine pens can supply up to 80 units in a single injection.

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