Oxamniquine should be given to a pregnant woman only if clearly needed. Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. Oxamniquine is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. If you experience dizziness, avoid these activities. The dosage of oxamniquine needed varies according to the geographic location where the infection was acquired (7). Revision Date: 2/13/04 4:02:18 PM. About 70% of a dose of oxamniquine is excreted as the 6-carboxy metabolite within 12 hours of a dose; traces of the 2-carboxy metabolite have also been detected in the urine. In the western hemisphere and western Africa, the adult oxamniquine dosage is 12–15 mg/kg given once. abdominal pain, decreased appetite, or vomiting. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into … to an unborn baby when a medication is taken during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant. Although oxamniquine and metrifonate have been used for schistosomiasis control, they are only effective against Schistosoma mansoni and S. haematobium, respectively. In northern and southern Africa, standard schedules are 15 mg/kg twice daily for 2 days. Myelography may identify discrete granulomatous masses that may be amenable to surgical removal (8). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2 to 10 mL/kg/dose IV administered over 5 to 30 minutes; larger doses (e.g., 10 mL/kg/dose) require the upper end of the infusion range. agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment. The use of any information on this site is solely at your own risk. The defined daily dose is 1 gram (by mouth) Side effects. Oxamniquine is available with a prescription under the brand name Vansil in 250 mg capsules. When split doses of these drugs were used, praziquantel achieved cure rates of 96, 95 and 89%, while the corresponding … Because oxacillin may cause phlebitis, slow IV infusion is recommended; many infuse the drug over a 1 hour administration time. Hydroquinone derivative prepared in the presence of Aspergillus sclerotium.Mechanism of action not fully explained, but it appears that drug-induced strong contractions and paralysis of worm musculature leads to immobilization of their suckers and dislodgment from their usual residence in mesenteric veins to the liver. Oxamniquine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. Oxamniquine is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Do not take oxamniquine without first talking to your doctor if you are pregnant. According to one systematic review, praziquantel is the standard treatment for S. mansoni infections and oxamniquine also appears effective. The cure rates, determined by the absence of eggs in stools, were 96, 93 and 74% at one, three and six months post-treatment for patients receiving a single dose (40 mg kg-1 body weight) of praziquantel, and 82, 78 and 78% for patients on a single dose (15 mg kg-1 body weight) of oxamniquine. Use caution when driving, operating machinery, or performing other hazardous activities. Stop taking oxamniquine and seek emergency medical attention if you experience an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives). Side effects other than those listed here may also occur. Quinoline derivatives and related substances. Before taking oxamniquine, tell your doctor about any other medical conditions that you have, especially liver disease, kidney disease, or a seizure disorder. The FDA categorizes medications based on safety for use during pregnancy. The Oxamniquine dose your doctor recommends will be based on the A reddish discoloration of urine, probably due to a metabolite of oxamniquine, has been reported. It is generally well tolerated following oral doses. Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. No studies have been done in animals, and no well-controlled studies have been done in Continue to take oxamniquine and talk to your doctor if you experience. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. A reddish discoloration of urine, probably due to a metabolite of oxamniquine, has been reported. The efficacy of the antischistosomal drugs praziquantel and oxamniquine was tested on four groups of Ethiopian sugar estate workers. VANSIL (Oxamniquine) David Schlossberg MD, FACP, FIDSA, FCPP. It prevents worms from growing or multiplying in your body. Coelho,2 C.M.F. The Oxamniquine dose your doctor recommends will be based on the following (use any or all that apply): the condition being treated other medical conditions you have other medications you are taking how you respond to this medication your weight your height your age your gender Oxamniquine is an "antihelmintic," or anti-worm, medication. Copyright 1996-2021 Cerner Multum, Inc. Oxamniquine is used only to treat infections caused by the worm Schistosoma mansoni. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Antunes,3 C.A.P. Chemotherapy protocols were (1) ALT, 60 mg/kg praziquantel (Pzq60); (2) AHT, one dose of 40 mg/kg Pzq followed by one dose of 20 mg/kg oxamniquine for one group and one dose of 40 mg/kg Pzq alone for the other group; (3) LIT, one dose of 40 mg/kg Pzq repeated every 3 months up to three doses. Do not take oxamniquine without first talking to your doctor if you are breast-feeding a baby. Optimal dosage schedules vary for different regions of the world. Dose-finding trials of oral oxamniquine in Rhodesia. Other, less serious side effects may be more likely to occur. Usual Adult Dose for Zollinger-Ellison Syndrome. Praziquantel and oxamniquine were given in single doses of 40 mg/kg body weight and 25 mg/kg, respectively. Store oxamniquine at room temperature away from moisture and heat. What happens if I miss a dose? This study sought to compare the effectiveness and side effects of praziquantel versus oxamniquine in treating 200 patients with Schistosoma mansoni infection and praziquantel versus metrifonate in treating 100 patients with S. haematobium infection. In geriatric patients, cautious dose selection is necessary because of decreased hepatic/renal/cardiac function and increased systemic exposure to cycloguanil; Dosing Modifications. This medication may be prescribed for other uses. combinâtion of oxâmniquine (7.5 mg/kg) plus prâziquantel (20 mg/kg) against either. 48 (Group 1) were treated with a single oral dose of oxamniquine (20mg/kg body-weight) and 43 (Group 2) received the placebo. Oxamniquine may cause dizziness. Actions. In the western hemisphere and western Africa, the adult oxamniquine dosage is 12–15 mg/kg given once. Ninety-one children with chronic schistosomiasis mansoni were selected for this double blind trial. Tavares,4 & A.S. da Cunha5 Objective To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide Select one or more newsletters to continue. Recommended dose In 2 Phase III NVAF clinical trials, approximately 95% of ELIQUIS® (apixaban) patients received this dose. Side Effects by Likelihood and Severity . Your pharmacist has more information about oxamniquine written for health professionals that you may read. Oxamniquine is a potent single-dose agent for treatment of S. mansoni infection in man, and it causes worms to shift from the mesenteric veins to the liver, where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. Seek medical attention in the case of a seizure. oxamniquine oral ; Side Effects by Severity ; oxamniquine oral Generic Name(s): oxamniquine . Ask your pharmacist any questions you have about this medication, especially if it is new to you. Therefore, this medication may be used if the potential benefits to the mother outweigh The dose of oxamniquine varies with the geographical origin of the S. mansoni infection, the age and hence the surface area of the patient. Treat to maintain ICP less than 20 mmHg and CPP between 40 and 50 mmHg. the potential risks to the unborn child. Clinical, laboratory and radiological examinations were performed before and after treatment. Hydroquinone derivative prepared in the presence of Aspergillus sclerotium.Mechanism of action not fully explained, but it appears that drug-induced strong contractions and paralysis of worm musculature leads to immobilization of their suckers and dislodgment from their usual residence in mesenteric veins to the liver. In northern and southern Africa, standard schedules are 15 mg/kg twice daily for 2 days. Optimal dosage schedules vary for different regions of the world. born with problems. Infuse appropriate dose at a rate to ensure that the entire dose is given before 10% or more of the drug is inactivated by the IV solution. Since only one or two doses are needed to treat this infection, you are not likely to miss a dose. Oxamniquine is usually taken in one or two doses that completely treat the infection. Oxamniquine is usually taken in one or two doses that completely treat the infection. Oxamniquine is "an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oral: 40 mg orally 2 times a day-Maximum dose: 240 mg/day Parenteral:-Initial dose: 80 mg via IV infusion every 12 hours, given over at least 2 minutes OR over 15 minutes-Maintenance dose: 80 mg via IV infusion every 8 to 12 hours, given over at least 2 minutes OR over 15 minutes Oxamniquine is used for treatment of schistosomiasis. Abdominal pain (4-21%) Cough (14-25%) Depression (undefined) Diarrhea (19-42%) Dyspnea (15-21%) Fever (14-40%) Headache (16-31%) Infection (18-22%) Insomnia (10-19%) Myalgia (undefined) Nausea (21-32%) Rash (22-46%) Rhinitis (5-24%) Vomiting (14-22%) Weakness (8-31%) 2 to 10 mL/kg/dose IV administered over 5 to 30 minutes; larger doses (e.g., 10 mL/kg/dose) require the upper end of the infusion range. Take oxamniquine exactly as prescribed by your doctor. Dosage Oxaminiquine's dosage details are as follows: Dose Single Dose Frequency Route Instructions Adult Dosage: 15 to 20 mg/kg: 18 (17.5) As recommended. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. Oxamniquine may be found in some form under the following brand names: This is not a complete list of Oxamniquinedrug interactions. 1. Availability. Actions. 1986 Jul;32(7):165-7. pregnant women. Individuals weighing less than 25 kg were treated with 20 mg/kg of oxamniquine syrup and others were given 12.5-15 mg/kg as capsules. Five categories - A, B, C, D, and X, are used to classify the possible risks All information on this site is provided "as-is" for informational purposes only and is not a substitute for medical advice or treatment. Side Effects. Cent Afr J Med. Available for Android and iOS devices. Data sources include IBM Watson Micromedex (updated 1 Apr 2021), Cerner Multum™ (updated 5 Apr 2021), ASHP (updated 6 Apr 2021) and others. Other brand or generic formulations may also be available. Ask your doctor or pharmacist for more information. We comply with the HONcode standard for trustworthy health information -. No well-controlled studies have been done in humans, though. [54460] [54503] [54549] [64013] Severe traumatic brain injury guidelines recommend 2 to 5 mL/kg/dose IV over 10 to 20 minutes. Drug interactions with oxamniquine are not well known. Dosage. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into … Store oxamniquine at room temperature away from moisture and heat. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. Take oxamniquine with food to lessen stomach upset. Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoniinfection: a controlled trial M.L.A. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Currently, praziquantel is the only drug used for treatment of all five species of human schistosomes. Infants, Children, and Adolescents. «Oxamniquine has been effective in some areas in which praziquantel is less effective (Stelma FF, et al: J Infect Dis 176:304, 1997). Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. In animal studies, pregnant animals were given this medication and had some babies You should consult with a medical professional if you have any questions about your health. It is generally well tolerated following oral doses. It is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine is used for treatment of schistosomiasis. 250 mg capsules. Antunes,3 C.A.P. Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoniinfection: a controlled trial M.L.A. following (use any or all that apply): Oxamniquine is available in the following doses: Oxamniquine is available in the following forms: Enter multiple addresses on separate lines or separate them with commas. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Ask your doctor or pharmacist for more information. Tavares,4 & A.S. da Cunha5 Objective To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide Take oxamniquine with food to lessen stomach upset. Tell your doctor and pharmacist about all medicines you are taking, so that they can monitor your therapy for interactions. Oxamniquine is used for treatment of schistosomiasis. There are no well-controlled studies that have been done in pregnant women. The defined daily dose is 1 gram (by mouth) Side effects. Praziquantel is a prescription drug used as anti-worm medication.It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.. Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water.Schistosoma worms are found in Africa, South America, Middle Eastern … Version: 3.03. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. JTriclabendazole may be effective in a dosage of 5 mg/kg once/day X 3 days or 10 mg/kg bid X 1 day (Calvopina M, et al: Trans R Soc Trop Med Hyg 92:566, 1998). Oxamniquine may also be used for purposes other than those listed in this medication guide. The Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Rarely, seizures have occurred, most often in patients who already have epilepsy or another seizure disorder. According to one systematic review, praziquantel is the standard treatment for S. mansoni infections and oxamniquine also appears effective. Coelho,2 C.M.F. Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. Take oxamniquine exactly as directed by your doctor. Ferrari,1 P.M.Z. CrCl . In South America, adults are given 15 mg/kg of body weight as a single oral dose; in children 20 mg/kg is preferred, given in two divided portions each of 10 mg/kg with an interval of 4–6 h between doses. Dosage Oral, 15 mg per kg of body weight two times a day for one day. Ferrari,1 P.M.Z. Oxamniquine is con-traindicated in pregnancy. This is an uncommon infection usually acquired through contact with freshwater in Africa. Seek emergency medical attention or call a poison control center near you. de V Clarke V, Blair DM, Weber MC, Garnett PA. Find patient medical information for oxamniquine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. 250 mg capsules. Dosage Oral, 15 mg per kg of body weight two times a day for one day. It is also not known whether oxamniquine passes into breast milk and how it might affect a nursing baby. Oxamniquine is not commercially available in the United States. Follow the directions on your prescription label carefully. Back to top. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Availability. Rafik Samuel MD, FACP, FIDSA, FCPP. Generic Name: oxamniquine (ox AM ni kwin)Brand Name: Vansil. Search for more papers by this author. The use of oral oxamniquine syrup or capsule in controlling endemic Schistosomia mansoni was studied in 191 residents of Castro Alves, northeast Brazil. [54460] [54503] [54549] [64013] Severe traumatic brain injury guidelines recommend 2 to 5 mL/kg/dose IV over 10 to 20 minutes. Take each dose with a full glass of water. Since only one or two doses are needed to treat this infection, you are not likely to miss a dose. Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. Twenty patients (Group 1) were treated with a single oral dose of oxamniquine (15-20mg/kg body weight) and 15 (Group 2) were treated with cloramphenicol (50mg/kg body weight, for 15-20 days). Dosage. The Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. You may need a lower dose or special monitoring if you have any of these conditions. Steroids are used to suppress the host response around the ectopic eggs (5,6). Dosage trial of a combination of oxamniquine and praziquantel in the treatment of schistosomiasis in Zimbabwean schoolchildren.