You take them using an inhaler or nebuliser. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9. The administration of carbocisteine to animals exposed to irritants indicates that the glycoprotein that is secreted remains normal; administration after exposure indicates that return to the normal state is accelerated. The use of Carbocisteine implies a decrease in the mucus viscosity and removal, either through the ciliary activity of the epithelium, or by the cough reflex. This association of this medicine with antitussive medication is not recommended. When your symptoms improve, your doctor may recommend 10ml, taken 3 times a day. Syrup: 15ml, taken 3 times a day. Tell your doctor or a pharmacist it you're taking any medicines that can cause bleeding or ulcers in your stomach. Carbocisteine is a mucolytic agent for the adjunctive therapy of respiratory tract disorders characterised by excessive, viscous mucus, including chronic obstructive airways disease. Its adverse effects include headache, nausea, vomiting, gastric discomfort and bleeding, diarrhea, and rash. By mouth. It has been used as an anti-infective nasal spray with mucolytic and expectorant action. Keywords : Carbocisteine, Acetonitrile, HPLC. It is used in cases of heavy cough with difficulty in spitting, especially during acute bronchitis. It has no impact on the psychophysical abilities so you can drive a car or operate machinery whil… MDL number MFCD00002614. Volume of distribution. Reduction of sputum viscosity. Musculoskeletal and connective tissue disorders. The aim of this study was to use Factorial Design (FD) to assess the stability of carbocisteine syrups subjected to forced degradation. It works by making your phlegm less thick and sticky. Syrup A clear amber coloured syrupy liquid. Capsules: two 375mg capsules, taken 3 times a day. Therefore it is expected an increase of cough and sputum. 2 - 5 years: 1.25 - 2.5ml, four times a day. Use promethazine syrup as ordered by your doctor. It may take up to 4 weeks before you notice your symptoms improving. 2. Measure the dose carefully using the oral syringe provided. 2. 14D Wendover Road, Rackheath Industrial Estate, Norwich, Norfolk, NR13 6LH. It has, however, been shown to be an effective mucolytic which is generally well tolerated with few adverse effects [1]. Carbocisteine is contraindicated in children aged less than 2 years. Protein binding. Pharmacotherapeutic group: Mucolytic, ATC code: R05CB03. There are a few other medicines that are prescribed for lung problems. Page last reviewed: 6 January 2020 Carbocistein Arzneimittelgruppen Schleimlösende Mittel Carbocistein ist ein Wirkstoff aus der Gruppe der Mucolytika, der für die Behandlung von Atemwegserkrankungen mit einer zähen Sekretbildung eingesetzt wird, zum Beispiel bei einem Erkältungshusten oder einer Bronchitis. 4 CLINICAL PARTICULARS 4.1 Therapeutic indications Carbocisteine is a mucolytic agent for the adjunctive therapy of respiratory tract disorders characterised by excessive, viscous mucus, including chronic obstructive airways disease. for seven days. These problems happen when too much mucus is made or the mucus is too sticky. The syrup comes with a plastic syringe or spoon to help you measure out the right dose. This can help if you have a condition that affects your lungs, including: Carbocisteine is available on prescription only. If there are, empty the syringe and try again. Take the carbocisteine packet, or the leaflet inside it, plus any remaining medicine with you. Each 5 ml of Carbocisteine contains 250 mg of carbocisteine. Carbocisteine Syrup is used for problems with the breathing passages (respiratory tract). Carbocisteine is a mucolytic agent for the adjunctive therapy of respiratory tract disorders characterised by excessive, viscous mucus, including chronic obstructive airways disease. Molecular Weight 179.19 . Measure liquid doses carefully. Take 30 to 60 minutes before travel if using for motion sickness. Date of first authorisation/renewal of the authorisation. Use in children less than 2 years of age. It can take time for the medicine to work and for phlegm to break up. Carbocisteine does not affect any type of contraception, including the combined pill and emergency contraception. However, with the carbocisteine sachets, common side effects can happen to 1 in 10 people. After dilution of the syrup preparation with a 4:1 mixture of a … Never take 2 doses at the same time. Keep taking your medicine even if you do not notice any improvement straightaway. You could also ask a pharmacist for advice on other ways to help you remember to take your medicine. This medicine contains sucrose. Het wordt gebruikt bij slijmhoest, onder meer bij de longziekten COPD en taaislijmziekte. Get someone else to drive you or call for an ambulance. Further information on the safety concerns and the recommendations . In these cases, treatment discontinuation is recommended. Carbocisteine is rapidly absorbed from the GI tract. 2 to 4 years: 1.25ml to 2.5ml of syrup, given 4 times a day, 5 to 11 years: 5ml of syrup, given 3 times a day, 12 to 17 years: 15ml of syrup, given 3 times a day. Pharmacokinetics: Absorption: Rapidly and well absorbed from the gastrointestinal tract. Close menu. Carbocisteine Capsule works by reducing the viscosity of sputum. Predicted data is generated using the US Environmental Protection Agency’s EPISuite™. Contraindications: Mucothiol paediatric is contraindicated for use in children less than 2 years age. Carbocisteine is rapidly absorbed in the gastrointestinal tract when taken orally with peak serum concentrations achieved within 1 to 1.7 hours. It is generally OK to take carbocisteine while breastfeeding, as the amount that passes into breast milk is unlikely to harm your baby. Taking carbocisteine can ease some of your symptoms by making it easier to cough up any phlegm. Introduction In this communication the present work proposes reverse phase high liquid chromatographic method for assay of carbocisteine from bulk drug and pharmaceutical formulation. You can report any suspected side effect using the Yellow Card safety scheme. No drug interactions have been identified. By decreasing the cough reflex there is a risk of obstruction of the airways as a consequence of the secretions amount increase. If your next dose is due in less than 2 hours, skip the missed dose and take your next one as normal. Description: Carbocisteine reduces goblet cell hyperplasia and therefore plays a role in the management of disorders characterised by abnormal mucous. However, if taking carbocisteine sachets makes you vomit or have severe diarrhoea for more than 24 hours, your contraceptive pills may not protect you from pregnancy. This makes it easier for you to cough up. Beilstein/REAXYS Number 1725012 . Carbocysteine is contraindicated in patients who have active peptic ulcer and in patients who are allergic to this drug. When suggestions are available use up and down arrows to review and ENTER to select. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Wash the syringe in warm water and allow to dry. Headache, dizziness, urinary incontinence, palpitations. These include: There is very little information about taking carbocisteine with herbal remedies and vitamin or mineral supplements. Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. If you need to go to A&E, do not drive yourself. Do not use a kitchen spoon as this will not give you the correct amount. Carbocisteine is rapidly absorbed from the GI tract. For Adult. It does not interact with other drugs. Carbocisteine is a type of medicine known as a mucolytic. Carbocisteine does not mix well with some medicines. Tell your doctor if these bother you or do not go away: In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to carbocisteine. 2. Although tests in mammalian species have revealed no teratogenic effects, is not recommended during the first trimester of pregnancy. This helps to make the mucus less thick and sticky, so it is easier to cough up. Yes, you can drive or ride a bike while taking carbocisteine. Read all information given to you. These problems happen when too much mucus is made or the mucus is too sticky. However, your doctor may stop you taking it if carbocisteine does not seem to be helping your symptoms after a month or so. Like all medicines, carbocisteine can cause side effects, although not everyone gets them. 200 ml or 300 ml type III amber glass bottles, with a white plastic inviolable closure HDPE/LDPE cap and a measuring device (oral syringe with polyethylene plunger and polypropylene cylinder with 5 ml capacity). A mucolytic helps you cough up phlegm (also called mucus or sputum). There is no firm evidence that carbocisteine affects male or female fertility. In most cases you will not have any symptoms. There are no preclinical data of relevance to the prescriber, which are additional to those already included in other sections of the SmPC. Carbocisteine helps to make it easier to cough up sputum. Next review due: 6 January 2023. Store out of the reach of children. Start typing to retrieve search suggestions. If you're taking carbocisteine capsules or liquid you're unlikely to have side effects. Tell your doctor before taking this medicine if you: It also comes as a liquid and as a syrup for children and people who find it difficult to swallow pills. Carbocisteine can therefore be demonstrated to have a role in the management of disorders characterised by abnormal mucus. Liquid carbocisteine formulations having improved properties Download PDF Info Publication number WO2014096497A1. It allows continued monitoring of the benefit/risk balance of the medicinal product. These are not all the side effects of carbocisteine. After use replace the bottle cap. Then put the tip of the syringe into the medicine bottle. Respiratory, thoracic and mediastinal disorders. For a full list see the leaflet inside your medicine packet. Dornase alfa and mannitol – these medicines are prescribed only for cystic fibrosis. Carbocisteine penetrates well into the lung and bronchial secretions. Frequencies are defined using the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1000 to ≤1/100); rare (≥1/10,000 to ≤1/1,000); very rare (≤1/10,000); not known (cannot be estimated from the available data). The method has been successfully used to analyze carbocisteine from active pharmaceutical ingredients. Equilibrium pharmacokinetics were established in healthy volunteers following administration of carbocisteine 375 mg capsules, 2 capsules t.d.s. Take with or without food. Step 3: Slowly pull back on the plunger until the syringe fills to the appropriate mark. It works best when it is taken regularly. Carbocisteine works by breaking down the mucus that is produced in the lungs. Carbocisteine should be used with caution in patients with wet cough. Carbocisteine is official in British Pharmacopoeia [[3-4], UPLC [5] and Ion-Chromatography [6] Available online Research Article ISSN : 0975 CODEN(USA) : JCPRC5 118 Carbocisteine in bulk and pharmaceutical Rele Rajan V. , D. G. Ruparel College, Matunga, Mumbai, second order derivative method have been developed and validated ulk and its tablet formulation. This medicine is not recommended for use in children and adolescents under the age of 18 years due to the alcohol content. Gastrointestinal disturbance (gastralgias, nausea and vomiting) are the most likely symptoms of Carbocisteine overdosage. It should be used with caution in patients with gastric and duodenal ulcer. Carin uses: Carin is indicated for- Acute bronchitis, Chronic bronchitis, Bronchial asthma, Upper respiratory tract inflammation (pharyngitis, laryngitis), Cystic fibrosis Bronchiectasis, Pulmonary tuberculosis, Drainage in chronic sinusitis and pneumonia, Drainage in otitis media in children. the appropriate dose is administered, especially if they have used Mucodyne Syrup in the past. Indications: Carbocisteine is a mucolytic agent for the adjunctive therapy of respiratory tract disorders characterised by excessive, viscous mucus, including chronic obstructive airways disease. Carbocisteine can be taken by adults and children from the age of 2 years. It has been used as an anti-infective nasal spray with mucolytic and expectorant action. have had an allergic reaction to carbocisteine or any other medicines in the past, have a stomach ulcer, or you've had stomach ulcers before, are pregnant, planning to get pregnant, or are breastfeeding, you get a skin rash that may include itchy, red, swollen, blistered or peeling skin, your mouth, face, lips, tongue or throat start swelling. If you are still being sick after more than a few days, or if your vomit contains blood, stop taking the medicine and see your doctor. Step 1: Check the measurements on the side of the syringe to see how much to fill it. Make sure there are not any large air bubbles in the syringe. Carbocisteine can be taken by adults and by children aged 2 years and older. This drug fluidifies the secretions (phlegm) present in the bronchi. Each 5 ml of Carbocisteine contains 7.5 mg of methyl parahydroxybenzoate. Carbocisteine Capsule may also be used for purposes not listed in this medication guide. Carbocisteine has no or negligible influence on the ability to drive and use machines. Therefore it is expected an increase of cough and sputum. Carbocisteine works by making phlegm (mucus) less sticky. Carbocisteïne verdunt taai slijm in de longen. Adverse reactions listed by System Organ Class. You can take carbocisteine with or without food. Are there similar medicines to carbocisteine? Values for derived pharmacokinetic values were CLS 331 ml.min-1; VD 105.2 L and VD 1.4 L/Kg. Use in patients with active peptic ulceration. Carbocisteine is a mucolytic that is administered orally or from a metered dose inhaler. This is because there is very little information to say whether it is safe. To bookmark a medicine you must sign up and log in. Continue typing to refine. If you forget a dose, take it as soon as you remember. Carbocisteine is not generally recommended when pregnant. Carbocisteine is a type of medicine called a mucolytic. Carbocisteine Capsule is used for Chronic obstructive pulmonary disease, Bronchiectasis and other conditions. Carbocisteine works by making phlegm (mucus) less sticky. overdose, Carbocisteine capsules, syrup drug Carbocisteine capsules, syrup, composition Carbocisteine capsules, syrup, Pharmaceuticals, Allopathic Products, Manufacturer exporter, Supplier Carbocisteine capsules, syrup India formulations , manufacturers Taj Products Pharmaceuticals Products, Manufacturer exporter, Supplier india Not enough research has been done to say whether it is safe. Usually, treatment with carbocisteine is for life. Carin contains Carbocisteine. syrup carbocisteine carbocistein improved stability Prior art date 1990-04-06 Legal status (The legal status is an assumption and is not a legal conclusion. Dosage is based upon an initial daily dosage of 2250 mg carbocisteine in divided doses, reducing to 1500 mg daily in divided doses when a satisfactory response is obtained e.g. It comes as capsules and as a syrup or a liquid that you drink. When your symptoms improve, your doctor may recommend one 375mg capsule, taken 4 times a day. From Wikipedia, the free encyclopedia Carbocisteine, also called carbocysteine, is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Carbocisteine shouldn’t be given with antitussive drugs and /or with drugs depressing bronchial secretions (including atropine – like drugs). Empirical Formula (Hill Notation) C 5 H 9 NO 4 S . This medicine contains methyl parahydroxybenzoate. Carbocisteine (S-carboxymethyl L-cysteine) has been shown in normal and bronchitic animal models to affect the nature and amount of mucus glycoprotein which is secreted by the respiratory tract. Look on the pill packet to find out what to do. WO2014096497A1 PCT/ES2013/070904 ES2013070904W WO2014096497A1 WO 2014096497 A1 WO2014096497 A1 WO 2014096497A1 ES 2013070904 W ES2013070904 W ES 2013070904W WO 2014096497 A1 WO2014096497 A1 WO 2014096497A1 Authority WO WIPO (PCT) … Each 5 ml of Carbocisteine contains 2877.5 mg of sucrose. Step 4: Place the end of the syringe into the mouth against the cheek and carefully press the plunger down slowly to gently release the medicine. It facilitates their evacuation by coughing. A simple and rapid densitometric method has been developed for determination of S-carboxymethylcysteine in syrup preparations. An increase in the acid:neutral glycoprotein ratio of the mucus and a transformation of serous cells to mucus cells is known to be the initial response to irritation and will normally be followed by hypersecretion. Most people have no side effects when taking this medicine. Yes, you can drink alcohol while taking carbocisteine. Initially 2.25 g daily in divided doses, then reduced to 1.5 g daily in divided doses, as condition improves. Carbocisteine can be used to help make mucus less sticky in respiratory tract problems such as bronchitis, chronic obstructive pulmonary disease or cystic fibrosis. The mean Tmax was 2.0 hours (range 1.0 –3.0); T½ 1.87 hours (range 1.4 – 2.5); KEL 0.387 hour-1 (range 0.28 – 0.50) and AUC0-7.5 was 39.26 (range 26.0 – 62.4). Use the measuring device to measure the appropriate amount, whether its use is for an adult or a child. Mucus produced in the lungs is also known as sputum or phlegm. This is for adults and for children aged 15 and older. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. ** Special attention in asthmatic patients due to the risk of bronchoconstriction occurrence (contraction of a muscle of the bronchial wall that leads to a reduction in airflow). Caution is advised in the administration of carbocisteine in individuals susceptible to gastroduodenal ulcers, as mucolytics have the capacity to destroy the gastric mucosal barrier. There is no known relevant data available on the effects of carbocisteine on fertility. This information is intended for use by health professionals. You could be having a serious allergic reaction and may need immediate treatment in hospital. One graduation, 0.25ml corresponds to 12.5mg of carbocisteine. Depending on why you need a mucolytic, your doctor might recommend an alternative medicine. This association of this medicine with antitussive medication is not recommended. Carbocisteine// A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. 2 Taking this medicine * Take this medicine by mouth * Carbocisteine Syrup comes with a measuring beaker * If you feel that this medicine is too weak or too strong, do not change the Carbocisteine European Pharmacopoeia (EP) Reference Standard Synonym: 3-carboxymethylthio-L-alanine, S-Carboxymethyl-L-cysteine CAS Number 638-23-3. For the full list of excipients, see section 6.1. Carbocisteine 250mg/5ml Syrup is used in the treatment of problems in the airways when there is too much mucus or when the mucus is too sticky, including chronic obstructive airways disease (COPD). Carbocisteine 250mg/5ml Syrup is … The liquid comes in individual sachets containing one dose. May cause allergic reactions (possibly delayed). Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine. You usually take this medicine 3 or 4 times a day. You can eat and drink normally while taking carbocisteine. To email a medicine you must sign up and log in.